Recent dynamics of forest fires in <i>Quercus suber</i> stands in Sardinia, Corsica and Catalonia

In this study, we analyzed the recent dynamics of forest fires in Quercus suber stands in Sardinia (Italy), Corsica (France), and Catalonia (Spain) for the period 2003-2015

Effect of 3 forms of fertilization on corn cultivation variety DAS 3383, La Troncal-Ecuador

The effect of 3 forms of edaphic fertilization, in corn (Zea mays) variety DAS 3383, on the variables (Plant height 30, 60, 90 DDS (cm); Cob insert height 70 DDS (cm) was evaluated; Cob length (cm); Cob diameter (cm); Rows of grain per ear; Weight 1000 grains (g); Cob / Grain ratio; Yield (Kg / ha-1); Economic analysis). The treatments were: T1= Supermagro enriched fertilizer: day 8 (25%), day 23 (25%), day 38 (50%); T2 = Conventional fertilizer 30 g / plant: day 8 (8-20-20% NPK), day 23 (15-3-20% NPK), day 38 (21-0-24% NPK); T3 = Witness (Without fertilizer), with 4 replicas. The experiment was carried out at the farm “Las Mercedes” of the La Troncal-Ecuador canton, lasted 130 days, under a Completely Randomized Block Design (DBCA), the data analysis was carried out through ANOVA, with Tukey’s test with (p&lt;0.05), the calculations were performed in the InfoStaf Statistical Package version 2019. The results showed significant differences in favor of the treatment (T2) Conventional Fertilizer for the variables plant height day 30 with 96.40 cm, height Insertion of the ear 70 days with 89.05 cm, diameter of the cob 4.76 cm, weight of 1000 grains 340.25 grams and yield of 9.67 Ton/ha, being the same that in the economic analysis determined the best marginal return rate, leaving a marginal rate of 9.08% representing that for every U$1.00 invested the producer can recover his invested dollar and obtain an additional U$ 0.09.Se evaluó el efecto de 3 formas de fertilización vía edáfica, en maíz (Zea mays) variedad DAS 3383, sobre las variables (Altura de planta 30, 60, 90 DDS (cm); Altura de inserción de mazorca 70 DDS (cm); Longitud de mazorca (cm); Diámetro de mazorca (cm); Hileras de grano por mazorca; Peso 1000 granos (g); Relación Tusa/Grano; Rendimiento (Kg/ha-1); Análisis económico). Los tratamientos fueron: T1= Fertilizante enriquecido supermagro: día 8 (25%), día 23 (25%), día 38 (50%); T2= Fertilizante convencional 30 g/planta: día 8 (8-20-20% NPK), día 23 (15-3-20% NPK), día 38 (21-0-24% NPK); T3= Testigo (Sin fertilizante), con 4 repeticiones. El experimento se realizó en la Hacienda “Las Mercedes” del cantón La Troncal-Ecuador, duró 130 días, bajo un Diseño de Bloques Completamente Aleatorizado (DBCA), el análisis de datos se realizó a través del ANOVA, con la prueba de Tukey con (p&lt;0.05), los cálculos se realizaron en el Paquete Estadístico InfoStaf versión 2019. Los resultados mostraron diferencias significativas a favor del tratamiento (T2) Fertilizante Convencional para las variables altura de la planta día 30 con 96.40 cm, altura inserción de la mazorca 70 días con 89.05 cm, diámetro de la mazorca 4.76 cm, peso de los 1000 granos 340.25 gramos y rendimiento de 9.67 Ton/ha, siendo este mismo que en el análisis económico determinó la mejor tasa de retorno marginal, dejando una tasa marginal del 9.08% representando que por cada U$1.00 invertido el productor puede recobrar su dólar invertido y obtener U$ 0.09 adicional

Comparación de 2 formas de fertilización en cultivo de maíz variedad DK 7500, La Troncal-Ecuador

The effect of 2 forms of soil fertilization on corn (Zea mayz L.) variety DK 7500 was evaluated at Las Mercedes, La Troncal – Ecuador Ranch, the treatments were: T1 = Supermagro enriched fertilizer: day 8 (25%), day 23 (25%), day 38 (50%); T2 = Conventional fertilizer 30 g / plant: day 8 (8-20-20% NPK), day 23 (15-3-20% NPK), day 38 (21-0-0-24% NPK), on the (Plant height 30, 60, 90 DDS (cm); Insertion height ear 70 DDS (cm); Ear length (cm); Ear diameter (cm); Rows of grain per ear; Weight 1000 grains (g); Tusa / Grain; Yield (kg / ha-1); Economic analysis. The experiment was run under a Completely Randomized Block Design with 4 replicates, the data were analyzed with ANOVA, the comparison of means was made with the Duncan Test (p &lt;0.05). The calculations were carried out in the InfoStaf Statistical Package version 2019. The results responded favorably to the conventional fertilizer treatment (T2), registering a greater ear length of 15.90 cm, ear diameter of 4.95 cm, tusa – grain ratio of 5.38. The types of fertilizers did not affected plant height at 30, 60 and 90 days, ear insertion on day 70, number of rows of kernels per ear, weight of 1000 kernels and yield. The partial budget analysis showed that the best marginal rate of return was obtained by the conventional fertilization treatment (T2), leaving a marginal rate of 27.27%, representing that for every U$1.00 invested in conventional fertilization, the producer recovers his dollar invested and obtains an additional U$ 0.27.Fue evaluado el efecto de 2 formas de fertilización vía edáfica en maíz (Zea mayz L.) variedad DK 7500, en la hacienda Las Mercedes La Troncal-Ecuador, los tratamientos fueron: T1= Fertilizante enriquecido Supermagro: día 8 (25%), día 23 (25%), día 38 (50%); T2= Fertilizante convencional 30 g/planta: día 8 (8-20-20% NPK), día 23 (15-3-20% NPK), día 38 (21-0-0-24% NPK), sobre la (Altura de planta 30, 60, 90 DDS (cm); Altura inserción mazorca 70 DDS (cm); Longitud mazorca (cm); Diámetro mazorca (cm); Hileras de grano por mazorca; Peso 1000 granos (g); Relación Tusa/Grano; Rendimiento (kg/ha-1); Análisis económico). El experimento se manejó bajo un Diseño de Bloques Completamente Aleatorizado con 4 réplicas, los datos se analizaron con ANOVA, la comparación de medias se efectuó con la Prueba de Duncan (p&lt;0.05). Los cálculos se realizaron en el Paquete Estadístico InfoStaf versión 2019. Los resultados respondieron favorablemente al tratamiento (T2) fertilizante convencional, registrando mayor longitud de mazorca 15.90 cm, diámetro de mazorca 4,95 cm, relación tusa-grano 5.38 los tipos de fertilización no incidieron sobre la altura de planta a 30, 60 y 90 días, inserción mazorca día 70, número de hilera de granos por mazorca, peso de los 1000 granos y rendimiento. El análisis de presupuesto parcial mostró que la mejor tasa de retorno marginal la obtuvo el tratamiento (T2) fertilización convencional, dejando una tasa marginal del 27.27% representando que por cada U$1.00 invertido en fertilización convencional el productor recobra su dólar invertido y obtiene U$ 0.27 adicional

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase&nbsp;1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation&nbsp;disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age&nbsp; 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score&nbsp; 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc&nbsp;= 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N&nbsp;= 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in&nbsp;Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in&nbsp;Asia&nbsp;and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Ecos de la academia: Revista de la Facultad de Educación, Ciencia y Tecnología - FECYT Nro 6

Ecos de la academia, Revista de la Facultad de Educación Ciencia y Tecnología es una publicación científica de la Universidad Técnica del Norte, con revisión por pares a doble ciego que publica artículos en idioma español, quichua, portugués e inglés. Se edita con una frecuencia semestral con dos números por año.En ella se divulgan trabajos originales e inéditos generados por los investigadores, docentes y estudiantes de la FECYT, y contribuciones de profesionales de instituciones docentes e investigativas dentro y fuera del país, con calidad, originalidad y relevancia en las áreas de ciencias sociales y tecnología aplicada.Modelos multidimensionales del bienestar en contextos de enseñanza- aprendizaje: una revisión sistemática. Nuevas tendencias para el área académica de la Publicidad en la zona 1 del Ecuador. Propuesta de un curso de escritura académica bajo la base de modelos experienciales. Aproximación al estudio de las emociones. Seguimiento a egresados y graduados para actualizar el perfil de egreso y profesional. Impacto de la Gerencia de Calidad en el clima organizacional en Educación Básica. Comunicación efectiva del gerente educativo orientada al manejo de conflictos en el personal docente. Meritocracia: Democratización o exclusión en el acceso a la educación superior en Ecuador. Asertividad y desempeño académico en estudiantes universitarios. La creatividad en la formación profesional. Aspectos metodológicos en el proceso de enseñanza- aprendizaje de la gimnasia en estudiantes de Educación Física. English Language Learning Interaction through Web 2.0 Technologies. La sistematización de la práctica educativa y su relación con la metodología de la investigación. El ozono y la oxigenación hiperbárica: una vía para mejorar la recuperación en lesiones deportivas. La labor tutorial: Independencia del aprendizaje en el contexto universitario. Motivación hacia la profesión docente en la Enseñanza Secundaria. El uso académico de Facebook y WhatsApp en estudiantes universitarios... La educación superior en Ecuador: situación actual y factores de mejora de la calidad. El Proyecto de Investigación “Imbabura Étnica”

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis:a randomised, double-blind, placebo-controlled, phase 2b trial

Background: Lung delivery of plasmid DNA encoding the CFTR gene complexed with a cationic liposome is a potential treatment option for patients with cystic fibrosis. We aimed to assess the efficacy of non-viral CFTR gene therapy in patients with cystic fibrosis. Methods: We did this randomised, double-blind, placebo-controlled, phase 2b trial in two cystic fibrosis centres with patients recruited from 18 sites in the UK. Patients (aged ≥12 years) with a forced expiratory volume in 1 s (FEV1) of 50–90% predicted and any combination of CFTR mutations, were randomly assigned, via a computer-based randomisation system, to receive 5 mL of either nebulised pGM169/GL67A gene–liposome complex or 0·9% saline (placebo) every 28 days (plus or minus 5 days) for 1 year. Randomisation was stratified by % predicted FEV1 (&lt;70 vs ≥70%), age (&lt;18 vs ≥18 years), inclusion in the mechanistic substudy, and dosing site (London or Edinburgh). Participants and investigators were masked to treatment allocation. The primary endpoint was the relative change in % predicted FEV1. The primary analysis was per protocol. This trial is registered with ClinicalTrials.gov, number NCT01621867. Findings: Between June 12, 2012, and June 24, 2013, we randomly assigned 140 patients to receive placebo (n=62) or pGM169/GL67A (n=78), of whom 116 (83%) patients comprised the per-protocol population. We noted a significant, albeit modest, treatment effect in the pGM169/GL67A group versus placebo at 12 months' follow-up (3·7%, 95% CI 0·1–7·3; p=0·046). This outcome was associated with a stabilisation of lung function in the pGM169/GL67A group compared with a decline in the placebo group. We recorded no significant difference in treatment-attributable adverse events between groups. Interpretation: Monthly application of the pGM169/GL67A gene therapy formulation was associated with a significant, albeit modest, benefit in FEV1 compared with placebo at 1 year, indicating a stabilisation of lung function in the treatment group. Further improvements in efficacy and consistency of response to the current formulation are needed before gene therapy is suitable for clinical care; however, our findings should also encourage the rapid introduction of more potent gene transfer vectors into early phase trials

A Case of Yellow Fever Vaccine–Associated Viscerotropic Disease in Ecuador

We report the first case of viscerotropic syndrome in Ecuador. Because of similarities between yellow fever and viscerotropic syndrome, the incidence of this recently described complication of vaccination with the 17D yellow fever vaccine is not known. There is a large population in South America that is considered at risk for possible reemergence of urban yellow fever. Knowledge of potentially fatal complications of yellow fever vaccine should temper decisions to vaccinate populations where the disease is not endemic

Effect of iron overload on the response to recombinant interferon-alfa treatment in transfusion-dependent patients with thalassemia major and chronic hepatitis C

Abstract The purpose of this study was to determine whether interferon-alfa (IFN-alpha) therapy benefits patients with transfusion-dependent thalassemia and chronic active hepatitis C, and whether their iron burden modifies the response to this therapy. We conducted a controlled trial of recombinant IFN-alpha (3 million units per square meter of body surface area, three times a week for 15 months) in 65 patients with thalassaemia major and chronic active hepatitis C; 14 of them were untreated control subjects. In 21 of the 51 treated patients, alanine aminotransferase values returned to normal within 6 months, and hepatitis C virus ribonucleic acid was no longer detected in serum; no changes were detected among control subjects. The response to IFN-alpha therapy was inversely related (p &lt; 0.002) to the liver iron burden as assessed by atomic absorption, the histologic semiquantitative method, or both methods. During 3 years of follow-up, two responder patients had relapses. We conclude that IFN-alpha represents a useful therapeutic option for children with transfusion-dependent thalassemia and chronic active hepatitis C with a mild to moderate iron burden

The Post-Translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms

In this review, we extensively describe the main post-translational modifications that give rise to the multiple proteoforms characterized to date in the human salivary proteome and their potential role. Most of the data reported were obtained by our group in over twenty-five years of research carried out on human saliva mainly by applying a top-down strategy. In the beginning, we describe the products generated by proteolytic cleavages, which can occur before and after secretion. In this section, the most relevant families of salivary proteins are also described. Next, we report the current information concerning the human salivary phospho-proteome and the limited news available on sulfo-proteomes. Three sections are dedicated to the description of glycation and enzymatic glycosylation. Citrullination and N- and C-terminal post-translational modifications (PTMs) and miscellaneous other modifications are described in the last two sections. Results highlighting the variation in the level of some proteoforms in local or systemic pathologies are also reviewed throughout the sections of the manuscript to underline the impact and relevance of this information for the development of new diagnostic biomarkers useful in clinical practice

Identification of thymosin beta 4 and beta 10 in paediatric craniopharingioma cystic fluid.

BACKGROUND: Adamantinomatous craniopharyngioma is the third most recurrent paediatric brain tumour. Although histologically benign, it behaves aggressively as a malignant tumour due to invasion of the hypothalamus and visual pathways. Surgery is still the first and almost the only mode of treatment, although serious damage can occur as a consequence of tumour localization. The proteomic characterization of the intracystic tumoural fluid could contribute to the comprehension of the tumorigenesis processes and to the development of therapeutic targets to reduce cyst volume, allowing less invasive surgery and/or delay of the radical resection of the tumour mass and the collateral serious effects. METHODS: Intracystic fluid was analysed by a LC-ESI-IT-MS top-down platform after acidification, deproteinization and chloroform liquid/liquid extraction. FINDINGS: Thymosin \u3b24 and \u3b210 peptides were for the first time identified in the intracystic fluid of adamantinomatous craniopharyngioma by low- and high-resolution MS analysis coupled with LC. The two peptides showed the same distribution trend in the analysed samples. Thymosin \u3b24 and \u3b210 were present in 77 % of the analysed samples. These peptides were not found in the cerebrospinal fluid available for two patients. INTERPRETATION: The presence of \u3b2-thymosins in the intracystic fluid of the tumour confirmed the secretion of these proteins in the extracellular environment. Due to their G-actin-sequestering activity and antiapoptotic and anti-inflammatory properties, these peptides could be strictly involved in both tumour progression and cyst development and growth